<p>CADRIA L 2MG INJECTION contains Doxorubicin which belongs to the group of medicines called Anti-cancer agents. It is used to treat certain types of cancers. It is used either alone or along with other anti-cancer medicines.</p>
<p>Cancer is a disease in which some of the cells of the body grow uncontrollably and spread to other parts of the body.</p>
<p> </p>
<p>Before receiving CADRIA L 2MG INJECTION, inform your doctor if you have or ever had heart disease, either before or during radiotherapy, had or having live or live-attenuated vaccinations, are currently taking or have recently taken Trastuzumab (used in the treatment of certain cancers).</p>
<p> </p>
<p>There are no adequate and well-controlled studies in pregnant women. Consult your doctor during breast-feeding before starting treatment with this medicine as it may pass through the breast milk and possibly harm your child. Consult your doctor for advice before receiving the medicine.</p>
<p> </p>
<p>The most common side effects of CADRIA L 2MG INJECTION are infection, lack of appetite, inflammation in the mouth, diarrhea, nausea, vomiting, reddening, swelling, pain, numbness and tingling in the palms and feet may also occur whilst being treated with this medicine.</p>
<p> </p>
<p>Hair loss is very common and may be quite severe, beard growth may stop in men, fever, feeling weak, chills, abnormal ECG (electrical trace of the heart) results, raised levels of liver enzymes (as detected by a blood test) can determine if the medicine is having an abnormal effect on your liver, weight increased in patients with early breast cancer.</p>
<h2> </h2>
<h2>USES OF CADRIA L 2MG INJECTION</h2>
<ul>
<li>Used to treat certain types of cancer</li>
</ul>
<h2> </h2>
<h2>HOW CADRIA L 2MG INJECTION WORKS</h2>
<p>CADRIA L 2MG INJECTION works by suppressing the activity of an enzyme (topoisomerase II) involved in the DNA multiplication of the cancer cells. On the other hand, this also forms harmful chemicals (free radicals) which cause damage to the DNA. This slowdown the growth of cancer cells and eventually works against them.</p>
<h2> </h2>
<h2>DIRECTIONS FOR USE</h2>
<p>CADRIA L 2MG INJECTION will be administered intravenously (IV) into the vein by your doctor or nurse. Your doctor will administer the correct dose and duration for you depending upon your age, body weight and disease condition.</p>
<h2> </h2>
<h2>SIDE EFFECTS OF CADRIA L 2MG INJECTION</h2>
<h2>COMMON</h2>
<ul>
<li>Infection</li>
<li>Lack of appetite</li>
<li>Inflammation in the mouth</li>
<li>Diarrhea</li>
<li>Nausea, vomiting</li>
<li>Hair loss</li>
<li>Beard growth may stop (in men)</li>
<li>Redness, swelling and blistering on the palms of the hands and soles of the feet (palmar-plantar erythrodysesthesia syndrome)</li>
<li>Chills</li>
<li>Weakness</li>
<li>Abnormal ECG</li>
<li>Raised levels of liver enzymes</li>
<li>Weight increased in patients with early breast cancer</li>
<li>Blood poisoning</li>
<li>Heart problems</li>
<li>Conjunctivitis (red watery eyes)</li>
<li>Lacrimation, excess tear production</li>
<li>Shortness of breath and swelling of the ankles</li>
<li>Increased heart rate</li>
<li>Inflammation of the throat and gullet</li>
<li>Stomach pain</li>
<li>Skin rashes, redness, hives</li>
<li>Nails and skin may appear darker than usual</li>
<li>Injection site reactions such as redness and swelling</li>
<li>Neutropenia</li>
<li>Thrombocytopenia</li>
<li>Malaise/asthenia</li>
<li>Infertility (in women)</li>
<li>Absence or decrease in sperm count (in men)</li>
</ul>
<h2> </h2>
<h2>UNCOMMON</h2>
<ul>
<li>Embolism (blockage in the bloodstream)</li>
</ul>
<h2> </h2>
<h2>RARE</h2>
<p>Stop receiving CADRIA L 2MG INJECTION and contact your doctor immediately if you experience any of the following side effects:</p>
<ul>
<li>Dizzy, feverish, short of breath with a tight chest or throat or having an itchy rash</li>
<li>Anemia (low red blood cell count)</li>
<li>Decrease in white blood cell counts which in turn causes an increase in infections and a raised temperature (fever)</li>
<li>Platelets can be affected which could make a bruise or bleed more easily</li>
<li>Decreased activity in bone marrow</li>
<li>Reddening of urine</li>
<li>Dehydration</li>
<li>Inflammation of veins</li>
<li>Irritation or bleeding in the intestines</li>
<li>Inflammation of the lining of the stomach</li>
<li>Heartburn</li>
<li>Soreness or ulcers in the mouth</li>
</ul>
<h2> </h2>
<h2>WARNING & PRECAUTIONS</h2>
<p><img src="https://www.netmeds.com/images/content/icons/pregnancy.jpg" /></p>
<p>PREGNANCY</p>
<p>There are no adequate and well-controlled studies in pregnant women. Consult your doctor before receiving CADRIA L 2MG INJECTION.</p>
<p><img src="https://www.netmeds.com/images/content/icons/breastfeeding.jpg" /></p>
<p>BREASTFEEDING</p>
<p>CADRIA L 2MG INJECTION is generally not recommended for use in breastfeeding women as it may pass through breast milk. Consult your doctor before receiving it.</p>
<p><img src="https://www.netmeds.com/images/content/icons/driving_and_using_machines.jpg" /></p>
<p>DRIVING AND USING MACHINES</p>
<p>There are no special precautions and can drive and operate machinery as long as you feel fully recovered after treatment with CADRIA L 2MG INJECTION.</p>
<p><img src="https://www.netmeds.com/images/content/icons/alcohol.jpg" /></p>
<p>ALCOHOL</p>
<p>Avoid consumption of alcohol while receiving CADRIA L 2MG INJECTION. Consult your doctor for advice.</p>
<p><img src="https://www.netmeds.com/images/content/icons/liver.jpg" /></p>
<p>LIVER</p>
<p>CADRIA L 2MG INJECTION is not recommended for use in patients having a hepatic impairment. Consult your doctor before receiving it.</p>
<p><img src="https://www.netmeds.com/images/content/icons/allergy.jpg" /></p>
<p>ALLERGY</p>
<p>Do not receive CADRIA L 2MG INJECTION if you are allergic (hypersensitivity) to Doxorubicin or other similar medicines called anthracyclines or anthracenediones or any of the other ingredients of this medicine.</p>
<p><img src="https://www.netmeds.com/images/content/icons/heart_disease.jpg" /></p>
<p>HEART DISEASE</p>
<p> </p>
<p>CADRIA L 2MG INJECTION is not recommended in patients with a current or previous history of cardiac impairment (severe myocardial insufficiency, recent myocardial infarction, severe arrhythmia) Consult your doctor before receiving it.</p>
<h2> </h2>
<h2>OTHERS</h2>
<p>CADRIA L 2MG INJECTION is not recommended for use if you have:</p>
<ul>
<li>Low blood cell counts</li>
</ul>
<p> </p>
<p>Before receiving CADRIA L 2MG INJECTION, inform your doctor if you have:</p>
<ul>
<li>Any other medical conditions</li>
</ul>
<p> </p>
<p><strong>Use in pediatrics:</strong></p>
<p>CADRIA L 2MG INJECTION should be used with caution in children. Your doctor will administer the right dose depends on your child’s age, body weight and disease condition. Consult your doctor before receiving the medicine.</p>
<p> </p>
<p><strong>Use in geriatrics:</strong></p>
<p>CADRIA L 2MG INJECTION should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before receiving the medicine.</p>
<h2> </h2>
<h2>INTERACTIONS</h2>
<p><strong>A. Drug-Drug interactions:</strong></p>
<p>Before receiving CADRIA L 2MG INJECTION, inform your doctor if you are taking any of the following medicine:</p>
<ul>
<li>Verapamil (used to treat high blood pressure)</li>
<li>Phenobarbital (used to control seizures)</li>
<li>Phenytoin (used to treat certain seizures)</li>
<li>St. John’s Wort (used to treat depression and mood stabilizer)</li>
<li>Cyclosporine</li>
<li>Calcium channel blockers (medicines for the heart)</li>
<li>Sorafenib (used to treat inoperable liver cancer and advanced kidney cancer)</li>
<li>Paclitaxel</li>
<li>Progesterone</li>
<li>Dexrazoxane</li>
<li>Cytarabine</li>
<li>Cyclophosphamide</li>
<li>Streptozocin (used to treat cancer of the pancreas)</li>
<li>Saquinavir (used to treat HIV)</li>
<li>Trastuzumab (used to treat certain cancers)</li>
</ul>
<p> </p>
<p><strong>Overdosage</strong>:</p>
<p>CADRIA L 2MG INJECTION will be administered to you only by a doctor or a nurse in a hospital and it is so unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual problems.</p>
<h2> </h2>
<h2>SYNOPSIS</h2>
<table border="0" cellpadding="1" cellspacing="1">
<tbody>
<tr>
<td><strong>Drug</strong></td>
<td>: </td>
<td>Doxorubicin</td>
</tr>
<tr>
<td><strong>Pharmacological Category</strong></td>
<td>: </td>
<td>Anthracyclin derivatives</td>
</tr>
<tr>
<td><strong>Therapeutic Indication</strong></td>
<td>: </td>
<td>Cancer</td>
</tr>
<tr>
<td><strong>Dosage Forms</strong></td>
<td>: </td>
<td>Injection</td>
</tr>
</tbody>
</table>
<h2> </h2>
<h2>MORE INFORMATION</h2>
<ul>
<li>Keep CADRIA L 2MG INJECTION out of reach of children</li>
<li>Store below 30°C</li>
</ul>
