<p> </p>
<p>KARPLAT 450MG INFUSION contains Carboplatin which belongs to the group of medicines called Anti-cancer agents. It is used to treat advanced ovarian cancer and small cell lung cancer. It is generally used in combination with other anti-cancer medicines to achieve better results.</p>
<p> </p>
<p>Advanced ovarian cancer is the cancer originated in ovary and spread to other parts of the body and small cell lung cancer is the cancer that occurs in tissues of the lungs. It is caused mainly due to smoking and characterized by symptoms such as chest pain, cough with blood, shortness of breath, tiredness, and weight loss.</p>
<p> </p>
<p>Before receiving KARPLAT 450MG INFUSION inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have fever or low blood counts before receiving KARPLAT 450MG INFUSION. KARPLAT 450MG INFUSION should not be used in pregnant or breastfeeding women.</p>
<p> </p>
<p>Men receiving KARPLAT 450MG INFUSION must not father a child during treatment with KARPLAT 450MG INFUSION and up to six months after stopping the therapy. Both men and women receiving KARPLAT 450MG INFUSION must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with KARPLAT 450MG INFUSION.</p>
<p> </p>
<p>The use of KARPLAT 450MG INFUSION may cause abnormal decrease in total blood counts. It may also cause nausea, vomiting, mouth sores, hearing loss, loss of taste, tingling or numbness of body parts, increased serum creatinine levels, difficult in passing urine, increased bilirubin levels in the blood and changes in vision.</p>
<p> </p>
<p>To avoid this, your doctor will closely monitor your blood count, liver functions, kidney functions, nerve functions and ear functions. However, consult your doctor if they trouble you.</p>
<h2> </h2>
<h2>USES OF KARPLAT 450MG INFUSION</h2>
<p>It is used either alone or in combination with other anticancer medicines to treat:</p>
<ul>
<li>Advanced ovarian cancer (cancer originated in ovary and spread to other parts of the body)</li>
<li>Small cell lung carcinoma (lung cancer)</li>
</ul>
<h2> </h2>
<h2>HOW KARPLAT 450MG INFUSION WORKS</h2>
<p>KARPLAT 450MG INFUSION is an anticancer medicine. It acts by damaging the genetic material (DNA and RNA) of the cancer cells. This prevents the cancer cells from growing and multiplying within the body.</p>
<h2> </h2>
<h2>DIRECTIONS FOR USE</h2>
<p>KARPLAT 450MG INFUSION will be given to you only by a doctor or a nurse into the vein as an intravenous infusion. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.</p>
<h2> </h2>
<h2>SIDE EFFECTS OF KARPLAT 450MG INFUSION</h2>
<h2>COMMON</h2>
<ul>
<li>Low blood counts (WBC, RBC, and platelets)</li>
<li>Nausea and vomiting</li>
<li>Stomach pain and cramps</li>
<li>Increased urea levels in the blood</li>
<li>Low magnesium, sodium, and potassium levels in the blood</li>
<li>Kidney damage, liver damage</li>
<li>Tingling, burning, pricking sensation or numbness of body parts</li>
<li>Loss of taste</li>
<li>Changes in vision</li>
<li>Decreased bone movements</li>
<li>Ringing in ears, loss of hearing</li>
<li>Chest tightness or wheezing</li>
<li>Diarrhea or constipation</li>
<li>Sore lips or mouth ulcers</li>
<li>Hair loss</li>
<li>Skin rash or itching</li>
<li>Back pain, joint pain, and muscle pain</li>
<li>Difficulty in urination</li>
<li>Extreme tiredness/weakness (asthenia)</li>
</ul>
<h2> </h2>
<h2>RARE</h2>
<ul>
<li>Temporary loss in eyesight</li>
</ul>
<p>Contact your doctor immediately if you experience any of the following side effects after receiving KARPLAT 450MG INFUSION:</p>
<ul>
<li>Signs of low platelet and WBC counts (such as infections, fever, sore throat, abnormal bleeding, and bruising)</li>
<li>Severe allergic reactions (such as swelling of the face, lips, tongue, and/or throat, itching and chest tightness which can lead to difficulty in breathing or swallowing)</li>
<li>Signs of tumor lysis syndrome (such as irregular heartbeat, kidney problems or abnormal blood cell count)</li>
<li>Signs of hemolytic-uremic syndrome (such as kidney damage, bloody urine, difficulty in urination along with extreme tiredness and shortness of breath with low RBC, WBC or platelet counts)</li>
<li>Signs of hemolytic anemia (such as extreme tiredness and shortness of breath with low RBC count)</li>
</ul>
<h2> </h2>
<h2>HOW TO MANAGE SIDE EFFECTS</h2>
<p><img src="https://www.netmeds.com/images/content/icons/diarrhea.jpg" /></p>
<p>Diarrhea</p>
<p>Drink plenty of fluids such as water, fruit juices or electrolytes to avoid dehydration in your body. Consult your doctor if your symptom worsens.</p>
<p><img src="https://www.netmeds.com/images/content/icons/mouth_ulcers.jpg" /></p>
<p>Mouth Ulcers</p>
<p>Use soft toothbrush to brush your teeth. Avoid eating spicy and acidic foods such as beverages, sodas, and processed foods. Also, you may can use over-the-counter pain-relieving oral gel to get some relief.</p>
<p><img src="https://www.netmeds.com/images/content/icons/skin_rash_or_itching.jpg" /></p>
<p>Skin Rash Or Itching</p>
<p>Do not scratch the affected area. Wear protective clothing while going outdoors. Regularly moisturize your skin. Consult your doctor if the symptoms worsen.</p>
<h2> </h2>
<h2>WARNING & PRECAUTIONS</h2>
<p><img src="https://www.netmeds.com/images/content/icons/pregnancy.jpg" /></p>
<p>PREGNANCY</p>
<p>CONTRAINDICATED</p>
<p>KARPLAT 450MG INFUSION is not recommended for use in pregnant women. Women of childbearing age must use a suitable contraceptive before and during treatment with KARPLAT 450MG INFUSION to avoid pregnancy and up to 6 months after treatment discontinuation. If you became pregnant while undergoing therapy with KARPLAT 450MG INFUSION, stop taking the medicine and contact your doctor immediately.</p>
<p><img src="https://www.netmeds.com/images/content/icons/breastfeeding.jpg" /></p>
<p>BREASTFEEDING</p>
<p>CONTRAINDICATED</p>
<p>KARPLAT 450MG INFUSION is not recommended for use in breast feeding women due to lack of proper safety data. Therefore, consult your doctor before receiving it.</p>
<p><img src="https://www.netmeds.com/images/content/icons/driving_and_using_machines.jpg" /></p>
<p>DRIVING AND USING MACHINES</p>
<p>USE WITH CAUTION</p>
<p>Do not drive or operate any heavy tools or machines if you experience any unpleasant symptoms (such as nausea, vomiting, worsening of eyesight, or changes in vision and sense of hearing) after receiving KARPLAT 450MG INFUSION.</p>
<p><img src="https://www.netmeds.com/images/content/icons/alcohol.jpg" /></p>
<p>ALCOHOL</p>
<p>CONTRAINDICATED</p>
<p>Consumption of alcohol is not recommended during treatment with KARPLAT 450MG INFUSION.</p>
<p><img src="https://www.netmeds.com/images/content/icons/kidney.jpg" /></p>
<p>KIDNEY</p>
<p>CONSULT YOUR DOCTOR</p>
<p>KARPLAT 450MG INFUSION is not recommended for use in patients with severe kidney diseases. It should be used with caution in patients with mild kidney problems. Therefore, consult your doctor before receiving it.</p>
<p><img src="https://www.netmeds.com/images/content/icons/liver.jpg" /></p>
<p>LIVER</p>
<p>USE WITH CAUTION</p>
<p>KARPLAT 450MG INFUSION should be used with caution in patients with liver disease. Therefore, consult your doctor before receiving it.</p>
<p><img src="https://www.netmeds.com/images/content/icons/allergy.jpg" /></p>
<p>ALLERGY</p>
<p>CONTRAINDICATED</p>
<p>Do not take KARPLAT 450MG INFUSION if you are allergic to Carboplatin or to other platinum containing cancer drugs (such as cisplatin and oxaliplatin).</p>
<p><img src="https://www.netmeds.com/images/content/icons/use_in_pediatrics.jpg" /></p>
<p>USE IN PEDIATRICS</p>
<p>CONTRAINDICATED</p>
<p>The safety and effectiveness of KARPLAT 450MG INFUSION in children have not been established. Therefore, KARPLAT 450MG INFUSION should not be used in children and adolescents (aged below 18 years) unless prescribed by a physician.</p>
<p><img src="https://www.netmeds.com/images/content/icons/use_in_geriatrics.jpg" /></p>
<p>USE IN GERIATRICS</p>
<p>USE WITH CAUTION</p>
<p>KARPLAT 450MG INFUSION should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before receiving it.</p>
<h2> </h2>
<h2>OTHERS</h2>
<p>KARPLAT 450MG INFUSION is not recommended for use if you:</p>
<ul>
<li>Have low blood cell counts (red blood cells, white blood cells and platelets)</li>
<li>Have a tumor that bleeds</li>
</ul>
<p>Before receiving KARPLAT 450MG INFUSION, inform your doctor if you:</p>
<ul>
<li>Have previously any cisplatin or with any other similar anti-cancer medicines in the past</li>
<li>Have headache, abnormal vision, altered mental functioning and/or seizures</li>
<li>Have fever or chills (or any signs of infection)</li>
</ul>
<h2> </h2>
<h2>INTERACTIONS</h2>
<p><strong>A. Drug-Drug interactions:</strong></p>
<p>Before receiving KARPLAT 450MG INFUSION, inform your doctor, if you are taking any of the following medicines such as:</p>
<ul>
<li>Medicines used to treat bacterial infections such as aminoglycosides (Ex. gentamicin, amikacin, capreomycin) or vancomycin</li>
<li>Medicines which can lower the number of blood cells (azacitidine, bosentan, carbidopa-levodopa)</li>
<li>Phenytoin, fosphenytoin (used to treat seizures)</li>
<li>Warfarin (a medicine used to prevent blood clot)</li>
<li>Live vaccines (yellow fever vaccine, typhoid vaccine, cholera vaccine)</li>
<li>Tacrolimus, sirolimus and ciclosporin (used to suppress the immune activity)</li>
<li>Diuretics (used to treat edema and high blood pressure) such as furosemide, torsemide</li>
</ul>
<p> </p>
<p><strong>Overdosage:</strong></p>
<p>KARPLAT 450MG INFUSION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.</p>
<h2> </h2>
<h2>SYNOPSIS</h2>
<table border="0" cellpadding="1" cellspacing="1">
<tbody>
<tr>
<td><strong>Drug</strong></td>
<td>: </td>
<td>Carboplatin</td>
</tr>
<tr>
<td><strong>Pharmacological Category</strong></td>
<td>: </td>
<td>Alkylating agents</td>
</tr>
<tr>
<td><strong>Therapeutic Indication</strong></td>
<td>: </td>
<td>Cancer (small cell lung cancer, advanced ovarian cancer)</td>
</tr>
<tr>
<td><strong>Dosage Forms</strong></td>
<td>: </td>
<td>Injection </td>
</tr>
</tbody>
</table>
<h2> </h2>
<h2>MORE INFORMATION</h2>
<ul>
<li>Keep KARPLAT 450MG INFUSION out of reach of children</li>
<li>Store at room temperature (not above 25°C) or in the refrigerator (between 2-8°C) depending upon the instructions given in the product label</li>
</ul>
