ZENFLOX OZ TABLET is a combination of Ornidazole and Ofloxacin which belongs to the group of medicines called Antibiotics. ZENFLOX OZ TABLET is used to treat various bacterial infections involving the blood (such as septicemia), brain (such as meningitis), lungs (such as pneumonia, bronchitis), ear and nose (such as sinusitis), urinary tract (such as cystitis), genital infections (including both the male and female genital organs), wound (post-operative infections), reproductive system (such as puerperal sepsis, septic abortion and endometritis) and stomach (such as peritonitis).

 

ZENFLOX OZ TABLET is also used as prophylaxis to prevent bacterial infections during surgical interventions (particularly involving the colon and in gynaecological operations).

Before initiating the treatment with ZENFLOX OZ TABLET, your doctor may recommend you to take relevant medical tests to understand your existing condition and to properly use this medicine.

 

Before taking ZENFLOX OZ TABLET inform your doctor if have heart disease (such as irregular heartbeat, valve disorder, poor heart function), kidney diseases (such as kidney failure or kidney injury), inflammation of the intestine, fits/seizure, autoimmune disease (such as multiple sclerosis), muscle-weakening diseases (such as myasthenia gravis), weak tendons (tendonitis, tendon rupture, rotator cuff), nerve pain (neuropathy), liver disease, psychiatric illness or emotional imbalances.

 

ZENFLOX OZ TABLET is not recommended for use in pregnant and breastfeeding women. ZENFLOX OZ TABLET is not recommended for use in children and adolescents (under 18 years of age) and it should be used with caution in elderly patients.

 

The common side effects of taking ZENFLOX OZ TABLET are nausea, vomiting, diarrhea, headache, itching and changes in taste sensation. Consult your doctor immediately if any of the side effects worsen during or after treatment with ZENFLOX OZ TABLET.

 

USES OF ZENFLOX OZ TABLET

To treat bacterial infections such as:


Lungs infections (Ex. pneumonia, bronchitis)
Sinus infections
Urinary tract infections
Meningitis
Septicemia
Puerperal sepsis, septic abortion and endometritis
Peritonitis
Post-operative wound infections
Gonorrhoea and some other genital infections (both the male and female genital organs)
Prophylaxis during surgical interventions (particularly involving the colon and in gynaecological operations)


 

HOW ZENFLOX OZ TABLET WORKS

ZENFLOX OZ TABLET is a combination of Ornidazole and Ofloxacin where Ornidazole kills parasites and bacteria that live in the absence of oxygen by generating harmful molecule which damages the DNA of the parasites and bacteria and ofloxacin is a quinolone antibiotic that kills bacteria by inhibiting the synthesis of bacterial DNA, hence helps to treat various infections.

 

DIRECTIONS FOR USE

Take ZENFLOX OZ TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose, duration and frequency of ZENFLOX OZ TABLET for you depending on your age, body weight and disease condition.

 

SIDE EFFECTS OF ZENFLOX OZ TABLET

COMMON


Headache, dizziness
Nausea, vomiting
Diarrhea
Itching
Sleep problems
External genital itching in women
Vaginal inflammation
Changes in taste sensation


 

UNCOMMON


Stomach pain or discomfort
Dry mouth
Loss of appetite
Fungal infection
Agitation, restlessness
Burning or irritation of the eye
Cough and inflamed sore nose or throat
Spinning sensation of the head (vertigo)


 

RARE


Fast heartbeat
Drowsiness
Confusion, nightmare
Decrease in blood sugar levels
Depression or hallucination (feeling or hearing things not there)
Changes in sensation of smell
Shortness of breath or wheezing
Excessive sweating
Feeling faint, lightheadedness due to low blood pressure
Hives
Rash with pimples
Pain or swelling around joints (tendonitis)
Excessive sweating, hot flushes


Stop taking ZENFLOX OZ TABLET and contact your doctor immediately if you experience any of the following side effects:


Severe allergic reactions (such as skin rash, itching, swelling of the face, lips, tongue and other parts of the body, difficulty in breathing or wheezing, blisters on the skin, sore throat, fever, headache)
Painful skin rashes with blisters and peeling or scaling of the skin in conditions such as steven-johnson syndrome and toxic epidural necrolysis
Abnormal heartbeat
Changes in behavior, psychosis, depression, hallucination, disorientation or fainting
Impaired vision or hearing
Severe fever, body chills or muscle pain
Swelling or rupture of tendons
Numbness or tingling sensation of the skin
Abnormal bleeding
Abnormal body movements like fits or seizure
Severe loose stools or diarrhea
Difficulty in passing urine or urine discoloration
Loss of consciousness
Abnormal body sugar level
Pain, burning, numbness and/or weakness especially in the feet and legs or hands and arms which indicates nerve damage
Stomach pain, itching, dark urine or yellowish discoloration of the skin and in the white part of the eye (jaundice)


 

HOW TO MANAGE SIDE EFFECTS



Diarrhea

Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve. 



Dry Mouth

Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.  



Headache

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.



Nausea And Vomiting

Take ZENFLOX OZ TABLET with or just after meals. Stick to simple meals. Avoid eating oily, fried or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.

WARNING & PRECAUTIONS



PREGNANCY

CONTRAINDICATED

ZENFLOX OZ TABLET is not recommended for use in pregnant women. Also, consult your doctor if you are suspecting or planning for pregnancy before taking ZENFLOX OZ TABLET.  



BREASTFEEDING

CONTRAINDICATED

ZENFLOX OZ TABLET is not recommended for use in breastfeeding women. Consult your doctor for advice before taking ZENFLOX OZ TABLET. 



DRIVING AND USING MACHINES

USE WITH CAUTION

Do not drive or operate any machines after taking ZENFLOX OZ TABLET if you feel dizzy, tired, sleepy, temporary loss of consciousness, less alert, spinning sensation of head, impaired vision, shivering, abnormal body movements and seizure/fits.



ALCOHOL

CONSULT YOUR DOCTOR

Do not consume alcohol while taking ZENFLOX OZ TABLET as it may aggravate your symptoms such as sleepiness, dizziness and eyesight problems.



KIDNEY

USE WITH CAUTION

ZENFLOX OZ TABLET should be taken with caution in patients with kidney disease or problems. Consult your doctor for advice before taking ZENFLOX OZ TABLET. 



LIVER

USE WITH CAUTION

ZENFLOX OZ TABLET should be taken with caution in patients with liver disease. Consult your doctor for advice before taking ZENFLOX OZ TABLET. 



ALLERGY

CONTRAINDICATED

Do not take ZENFLOX OZ TABLET if you are allergic to Ofloxacin or Ornidazole. Also, inform your doctor if you are allergic to other quinolone antibiotics such as ciprofloxacin, norfloxacin.



HEART DISEASE

USE WITH CAUTION

ZENFLOX OZ TABLET should be taken with caution in patients with leaking heart valves (heart valve regurgitation), endocarditis (infection of the heart), irregular or slow heartbeat, family history of prolonged QT interval, weak heart (heart failure), history of heart attack (myocardial infarction). Consult your doctor for advice before taking ZENFLOX OZ TABLET.  



USE IN PEDIATRICS

CONTRAINDICATED

ZENFLOX OZ TABLET is not recommended for use in children and adolescents under 18 years of age. Consult your child’s doctor for advice.



USE IN GERIATRICS

USE WITH CAUTION

ZENFLOX OZ TABLET should be used with caution in elderly patients. Your doctor will decide the dose, duration and frequency of ZENFLOX OZ TABLET depending on the severity of your existing condition and other comorbidity conditions.

 

OTHERS

ZENFLOX OZ TABLET is not recommended for use if you:


Have epilepsy or at risk of fits
Have any pre-exisiting central nervous system (CNS) disorders
Have history of inflammation and swelling of the tendons (tendonitis) especially after the treatment with quinolone antibiotics such as ciprofloxacin, norfloxacin or nadifloxacin
Are suffering from or have a family history of glucose-6-phosphate dehydrogenase deficiency (an inherited disorder that affects the red blood cells)


Before taking ZENFLOX OZ TABLET, inform your physician if you:


Have an enlargement or bulge of a large blood vessel (aortic aneurysm or large vessel peripheral aneurysm)
Experienced a previous episode of aortic dissection (a tear in the aorta wall)
Have a family history of aortic aneurysm or aortic dissection
Have other risk factors or predisposing conditions (Ex. connective tissue disorders such as marfan syndrome or ehlers- danlos syndrome, turner syndrome, sjogren’s syndrome (an inflammatory autoimmune disease)
Have vascular disorders such as takayasu arteritis, giant cell arteritis, behcet’s disease and high blood pressure or atherosclerosis, rheumatoid arthritis
Have or ever had a history of mental illness
Have salt imbalance in the blood (especially low level of potassium or magnesium in the blood)
Illness of the nervous system called myasthenia gravis (muscle weakness)
Are diabetic or suffer from low blood sugar
Have due to urine tests for porphyrin (a pigment in the blood) or for opiates (strong painkillers)


 

INTERACTIONS

A. Drug-Drug interactions:

Before taking ZENFLOX OZ TABLET, inform your doctor if you are taking any of the following medicines:


Antipsychotics such as olanzapine, clozapine (used to treat psychosis)
Cyclosporin (used to prevent organ rejection after transplant)
Quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, dofetilide, ibutilide, pentoxifylline (used to treat irregular heart rhythm)
Lithium or tricyclic antidepressants such as clomipramine, amitriptyline (used to treat depression)
Macrolides such as erythromycin, clarithromycin, azithromycin (used to treat bacterial infection)
Vecuronium bromide (used to relax muscles)
Phenytoin, phenobarbital (used to treat epilepsy)
Didanosine (used in the treatment of HIV infection)
Furosemide (used to treat body fluid retention)
Sucralfate, cimetidine (used to treat stomach ulcer)
Antacids containing magnesium or aluminium (used for indigestion)
Corticosteroids such as prednisolone, dexamethasone (used to treat inflammation)
Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or diclofenac (used to pain and inflammation)
Theophylline (used to treat asthma)
Insulin, glibenclamide (used to treat diabetes)
Probenecid (used to treat gout)
Methotrexate (used for rheumatism)
Warfarin, acenocoumarin, phenprocoumon (used to treat or prevent blood clot)
Medicines or dietary supplements that contain iron (for anemia) or zinc
Herbal medicines


 

Overdosage:

If you or anyone else accidentally takes too much of ZENFLOX OZ TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of ZENFLOX OZ TABLET include confusion, dizziness, loss of consciousness, seizure or fit and nausea.

 

SYNOPSIS




Drug
:  
Ornidazole and Ofloxacin


Pharmacological Category
:  
Nitroimidazole and Fluoroquinolones


Therapeutic Indication
:  
Various bacterial infections


Dosage Forms
:  
Tablet, Capsule, Infusion, Injection, Syrup, Oral Suspension




 

MORE INFORMATION


Keep ZENFLOX OZ TABLET out of reach from children
Store ZENFLOX OZ TABLET at room temperature